Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cells

Abstract The advent of whole Upper Wire Harness genome sequencing has revealed that common laboratory strains of human cytomegalovirus (HCMV) have major genetic deficiencies resulting from serial passage in fibroblasts.In particular, tropism for epithelial and endothelial cells is lost due to mutations disrupting genes UL128, UL130, or UL131A, whic

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Re-Examination of the Decadal Change in the Relationship between the East Asian Summer Monsoon and Indian Ocean SST

This study examines the decadal change in the relationship between two major Indian Ocean (IO) sea surface temperature patterns, namely the Indian Ocean dipole (IOD) and northern IO and the East Asia summer monsoon (EASM) in the early 2000s.In 1991–1999, the former epoch, the interannual Upper Wire Harness variability of EASM was associated w

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